The Sub-Saharan Africa Region was established in 1997 with its headquarters located in Accra, Ghana. Currently HCJB Global Voice is involved in broadcasting in 32 countries. The mission also partners with local people to plant radio stations, produce programming in major languages for distribution via satellite, and training radio workers across the region in technical and programming areas.

HCJB Global Hands is also at work with medical partners in countries such as the Democratic Republic of Congo, Malawi, Ghana and South Africa.